Jeffrey Magee, M.D., Ph.D.

Jeffrey Magee, M.D., Ph.D.

Cancer biology, stem cell, hematopoiesis, leukemia, developmental biology **Trainees in the Magee lab will gain experience in mouse models of human blood cancers, hematopoietic stem cell biology, genomics and translational research.

Assistant Professor

Developmental, Regenerative and Stem Cell Biology Program
Molecular Genetics and Genomics Program
Molecular Cell Biology Program

  • Cancer biology, stem cell, hematopoiesis, leukemia, developmental biology

  • Developmental context and genetic variation as underlying mechanisms of childhood cancer

    Abstract: The Magee lab studies the differences between childhood and adult leukemia. Our goal is to understand why children get leukemia when they are not subject to the effects of aging, environmental exposures and inflammation that can contribute to malignancies in adults. We are using mice to model the effects of different infant and adult leukemia-causing mutations at different ages. We have discovered that mutations have different effects on gene expression, and ultimately cell fate, at different stages of life. We are now working to decode the interactions between mechanisms that regulate development of the blood system and the mutations that cause leukemia. Furthermore, we are working to model the effects that rare, inherited genetic variants can have on infant leukemia development. These studies will ultimately lead to new treatments for childhood and adult leukemia.