Our research is motivated by the spectacular diversity of cell shapes in nature, which underlies the viability and adaptibility of organisms. In plants, nanoscale protein polymers called microtubules determine cell shape by spatially organizing the rigid cell wall. We want to understand how complex cortical microtubule arrays are created in the absence of a dedicated organizing center like the centrosome of animal cells and how these arrays orchestrate ordered deposition of cell wall material. To elucidate the underlying molecular mechanisms, we use a multi-disciplinary and multi-scale approach combining live-imaging, in vitro reconstitution at the single-molecule level, molecular genetics and computational modeling.
Contact us at:
Washington University in St. Louis
1 Brookings Dr, CB 1137
St. Louis, MO 63130.
Lab phone: (314)-935 9080