JBC Paper of the Week: Structure and mechanism of isopropylmalate dehydrogenase (Lee et al., 2016 J Biol Chem 291, 13421

Plants are amazing chemists capable of generating an array of compounds with a range of biological activities. Understanding the biosynthesis of these compounds at a structural and mechanistic level is the foundation for manipulating their assembly either in vitro or in vivo. Our research employs biochemistry, protein engineering, and x-ray crystallography to investigate the molecular basis of biological processes in plants, microbes, and nematodes.