Conformational changes in the di-domain structure of Arabidopsis phosphoethanolamine methyltransferase leads to active site formation (Lee & Jez, 2017 J Biol Chem 292, 21690-702)

Plants are amazing chemists capable of generating an array of compounds with a range of biological activities. Understanding the biosynthesis of these compounds at a structural and mechanistic level is the foundation for manipulating their assembly either in vitro or in vivo. Our research employs biochemistry, protein engineering, and x-ray crystallography to investigate the molecular basis of biological processes in plants, microbes, and nematodes.

June 12, 2019

What makes stevia sweet?

Our PNAS paper on the enzyme that makes stevia is highlighted in the Record.  Image painted by Caroline Focht.