JBC Paper of the Week: An alternative mechanism for the methylation of phosphoethanolamine catalyzed by Plasmodium falciparum phosphoethanolamine methyltransferase (Saen-oon & Lee et al., 2014 J Biol Chem 289, 33815)

Plants are amazing chemists capable of generating an array of compounds with a range of biological activities. Understanding the biosynthesis of these compounds at a structural and mechanistic level is the foundation for manipulating their assembly either in vitro or in vivo. Our research employs biochemistry, protein engineering, and x-ray crystallography to investigate the molecular basis of biological processes in plants, microbes, and nematodes.