A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana (Meesters et al. 2014 Nature Chem Biol 10, 830)

Plants are amazing chemists capable of generating an array of compounds with a range of biological activities. Understanding the biosynthesis of these compounds at a structural and mechanistic level is the foundation for manipulating their assembly either in vitro or in vivo. Our research employs biochemistry, protein engineering, and x-ray crystallography to investigate the molecular basis of biological processes in plants, microbes, and nematodes.