Molecular basis of the evolution of alternative tyrosine biosynthesis routes in plants (Schenck & Holland et al., 2017 Nature Chem Biol 13, 1029-35)

Plants are amazing chemists capable of generating an array of compounds with a range of biological activities. Understanding the biosynthesis of these compounds at a structural and mechanistic level is the foundation for manipulating their assembly either in vitro or in vivo. Our research employs biochemistry, protein engineering, and x-ray crystallography to investigate the molecular basis of biological processes in plants, microbes, and nematodes.