Soon Goo Lee

Soon Goo Lee

Graduate Student - Plant Biology Program, Olin Biomedical Fellow, 2007-2012; Postdoc, 2012-2017; Research Scientist, 2017-

Vallone A, D'Alessandro SD, Brogi S, Brindisi M, Chemi G, Alfano G, Lamponi S, Lee SG, Jez JM, Koolen K, Dechering K, Saponara S, Fusi F, Gorelli B, Taramelli D, Parapini S, Caldelari R, Campiani G, Gemma S, Butini S (2018) Antimalarial agents against both sexual and asexual parasite stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues.  Eur J Med Chem 150, 698-718

Lee SG*, McClerklin S*, Harper CP, Nwumeh R, Jez JM, Kunkel BN (2018) Indole-3-acetaldehyde dehydrogenase-dependent auxin synthesis contributes to virulence in Pseudomonas syringae strain DC3000. PLoS Pathogens 14, e1006811

Lee SG, Jez JM (2017) Conformational changes in the di-domain structure of Arabidopsis phosphoethanolamine methyltransferase leads to active site formation.  J Biol Chem 292, 21690-702 (*JBC Editors Pick & Cover Art)

Hackenberg D, McKain MR, Lee SG, Roy Choudhury S, McCann T, Schreirer S, Harkess A, Pires JC, Wong GKS, Jez JM, Kellogg EA, Pandey S (2017) Galpha:RGS protein pairs maintain functional compatibility and conserved interaction interfaces throughout evolution despite frequent loss of RGS proteins in plants.  New Phytologist 216, 562-75

Schenck CA*, Holland CK*, Schneider MR, Men Y, Lee SG, Jez JM, Maeda HA (2017) Molecular basis of the evolution of alternative tyrosine biosynthesis pathways in plants.  Nature Chem Biol 13, 1029-35

Cascella B, Lee SG, Singh S, Jez JM, Mirica LM (2017) The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4a/JMJD2A.  Chem Commun 53, 2174-7

Jez JM, Lee SG, Sherp AM (2016) The next green movement: plant biology for the environment and sustainability. Science 353, 1241-4

Lee SGNwumeh R, Jez JM (2016) Structure and mechanism of isopropylmalate dehydrogenase from Arabdiopsis thaliana: insights on leucine and aliphatic glucosinolate biosynthesis.  J Biol Chem 291, 13421-30 (*JBC Paper of the Week)

Herrmann J, Nathin D, Lee SG, Sun T, Jez JM (2015) Recapitulating the structural evolution of redox regulation in adenosine-5'-phosphosulfate kinase from cyanobacteria to plants.  J Biol Chem 290, 24705-14

Cahoon RE, Lutke WK, Cameron JC, Chen S, Lee SG, Rivard RS, Rea PA, Jez JM (2015) Adaptive engineering of phytochelatin-based heavy metal tolerance.  J Biol Chem 290, 17321-30

Lee SG*, Bhuiya MW*, Jez JM, Yi O (2015) Structure and mechanism of ferulic acid decarboxylase (FDC1) from Sacchromyces cerevisiae.  Appl Environ Micro 81, 4216-23

Korasick DA, Chatterjee S, Tonelli M, Dashti H, Lee SG, Westfall CS, Fulton DB, Andreotti AH, Amarasinghe GK, Strader LC, Jez JM (2015) Defining a two-pronged structural model for PB1 domain interaction in plant auxin responses. J Biol Chem 290, 12868-78

Lee SG*, Saen-oon S*, Jez JM, Guallar V (2014) An alternate mechanism for the methylation of phosphoethanolamine catalyzed by Plasmodium falciparum phosphoethanolamine methyltransferase.  J Biol Chem 289, 33815-25 (*JBC Paper of the Week) 

Lee SG, Krishnan HB, Jez JM (2014) Structural basis for regulation of nodulation and symbiosis gene expression in Rhizobium by NolR.  Proc Natl Acad Sci USA 111, 6509-14

Korasick DA, Westfall CS, Lee SG, Nanao M, Dumas R, Hagen G, Guilfoyle TJ, Jez JM, Strader LC (2014) Molecular basis for auxin response factor protein interaction and the control of auxin response repression.  Proc Natl Acad Sci USA 111, 5427-32

Lee SG, Jez JM (2014) Nematode phospholipid metabolism: an example of closing the genome-structure-function circle.  Trends Parasitol 30, 241-50

Herrmann J, Ravilious GE, McKinney SE, Westfall CS, Lee SG, Baraniecka P, Giovannetti M, Kopriva S, Krishnan HB, Jez JM (2014) Structure and mechanism of soybean ATP sulfurylase - the committed step in plant sulfur assimilation.  J Biol Chem 289, 10919-29

Yi H, Dey S, Kumaran S, Lee SG, Krishnan HB, Jez JM (2013) Structure of soybean serine acetyltransferase and formation of the cysteine regulatory complex as a molecular chaperone.  J Biol Chem 288, 30463-72

Lee SG, Jez JM (2013) Evolution of structure and mechanistic divergence in di-domain methyltransferases from nematode phosphocholine biosynthesis.  Structure 21, 1778-87

Ravilious GE, Herrmann J, Lee SG, Westfall CS, Jez JM (2013) Kinetic mechanism of a dimeric ATP sulfurylase from plants.  Biosci Rep 33, e00053

Lallemand A, Zubieta C, Lee SG, Wang Y, Acajjaoui S, Timmins J, McSweeney S, Jez JM, McCarthy JG, McCarthy AA (2012) Structural basis for the biosynthesis of the major chlorogenic acids found in coffee.  Plant Physiol 160, 249-60

Lee SG, Alpert TD, Jez JM (2012) Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine.  Bioorg Med Chem Lett 22, 4990-3

Lee SG, Kim YC, Alpert TD, Nagata A, Jez JM (2012) Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum - an anti-parasitic drug target.  J Biol Chem 287, 1426-34 (*JBC Paper of the Week)

Lee SG, Haakenson W, McCarter JP, Williams DJ, Hresko MC, Jez JM (2011) Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode Haemonchus contortusJ Biol Chem 286, 38060-8

Lee SG, Jez JM (2011) The phosphobase methylation pathway in Caernorhabditis elegans: a new route to phospholipids in animals.  Curr Chem Biol 5, 183-8