Washington University (2008-present)

168.  Edwards RL, Heueck I, Lee SG, Shah IT, Jezewski AJ, Miller JJ, Mikati MO, Wang X, Brothers RC, Heidel KM, Burnham CA, Alvarez S, Fritz SA, Dowd CS, Jez JM, Odom-John AR (2019) Potent, specific MEPicides for treatment of zoonotic staphylococci.  submitted.

167.  Burke JR, La Clair JJ, Philippe RN, Pabis A, Corbella M, Jez JM, Cortina GA, Kaltenbach M, Bowman ME, Louie GV, Woods KB, Nelson AT, Tawfik DS, Kamerlin SCL, Noel JP (2019) Bifunctional substrate activation via an arginine residue drives catalysis in chalone isomerases.  ACS Catalysis 9, 8388-96

166.  Powers SK, Holehouse AS, Korasick DA, Schreiber KH, Clark NM, Jing H, Emenecker R, Han S, Tychsen E, Hwang I, Sozzani R, Jez JM, Pappu RV, Strader LC (2019) Nucleo-cytoplasmic partitioning of ARF proteins controls auxin responses in Arabidopsis thaliana.  Molecular Cell (in press)

165.  Jez JM (2019) Structural biology of plant sulfur metabolism: from sulfate to glutathione.  J Exp Bot 70, 4089-103

164.  Kumar R*, Lee SG*, Augustine R*, Reichelt M, Vassao DG, Palavalli MH, Allen A, Gershenzon J, Jez JM, Bisht NC (2019) Molecular basis of the evolution of methylthioalkylmalate synthase and the diversity of methionine-derived glucosinolates.  Plant Cell 31, 1633-47

163.  Lee SG, Salomon E, Yu O, Jez JM (2019) Molecular basis for branched steviol glucoside biosynthesis.  Proc Natl Acad Sci USA 116, 13131-6

162.  Jez JM (2019) Plant nitrilases:  a new job for an old enzyme.  Biochem J 476, 1105-7

161.  Sherp AM, Lee SG, Schraft E, Jez JM (2018) Modification of auxinic phenoxyalkanoic acid herbicides by the acyl acid amido synthetase GH3.15 from Arabidopsis.  J Biol Chem 293, 17731-8

160.  Fellows R, Russo C, Silva C, Lee SG, Jez JM, Chisholm J, Zubieta C, Nanao M (2018) A multisubstrate reductase from Plantago major: structure and function in the short-chain reductase family.  Sci Rep 8, 14796

159.  Holland CK, Jez JM (2018) Arabidopsis:  the original plant chassis organism.  Plant Cell Rep 37, 1359-66

158.  Stewart CN, Patron N, Hanson AD, Jez JM (2018) Plant metabolic engineering in the synthetic biology era:  plant chassis selection.  Plant Cell Rep 37, 1357-8

157.  Anbar A, Elgin S, Jez J, O'Dowd D, Shapiro B, Zaman M (2018) Improving societies' harassament policies.  Science 361, 984-5

156.  Holland CK, Jez JM (2018) Structural biology of jasmonic acid metabolism and responses in plants.  In Plant Structural Biology: Hormonal Regulations (Helatko J, Takoshima T, Eds.), pp 67-82 Springer-Verlag, NY

155.  Hanson AD, Jez JM (2018) Synthetic biology meets plant metabolism.  Plant Sci 273, 1-2

154.  Holland CK, Jez JM (2018) Reaction mechanism of prephenate dehydrogenaes from the alternative tyrosine biosynthesis pathway in plants.  ChemBioChem 19, 1132-6

153.  Krishnan HB, Jez JM (2018) The promise and limits for enhancing sulfur-containing amino acid content in soybean seed.  Plant Sci 272, 14-21

152.  Jez JM (2018) Introduction to the thematic minireview series:  green biological chemistry.  J Biol Chem 293, 5016-7

151.  Holland CK, Berkovich DA, Kohn ML, Maeda H, Jez JM (2018) Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis.  Plant J 94, 304-14

150.  Vallone A, D'Alessandro S, Brogi S, Brindisi M, Chemi G, Alfano G, Lamponi S, Lee SG, Jez JM, Koolen KJM, Dechering KJ, Saponara S, Fusi F, Gorelli B, Taramelli D, Parapini S, Caldelari R, Campiani G, Gemma S, Butini S (2018) Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-cholorophenyl)furan-2-yl]-N-[piperidin-4-yl)methyl]methanamine (MMV019918) and analogues.  Eur J Med Chem 150, 698-718

149.  Sherp AM, Westfall CS, Alvarez S, Jez JM (2018) Arabidopsis thaliana GH3.15 acyl acid amido synthetase has a highly specific substrate preference for the auxin precursor indole-3-butryic acid.  J Biol Chem 293, 4277-88

148.  Krishnan HB, Song B, Oehrle NW, Cameron JC, Jez JM (2018) Impact of overexpression of cytosolic isoform of O-acetylserine sulfhydrylase on soybean nodulation and nodule metabolome.  Sci Rep 8, 2367

147.  McClerklin SA*, Lee SG*, Harper CP, Nwumeh R, Jez JM, Kunkel BN (2018) Indole-3-acetaldehyde dehydrogenase-dependent auxin synthesis contributes to virulence of Pseudomonas syringae strain DC 3000.  PLoS Pathogens 14, e1006811

146.  Cascella B, Jez JM (2018) Beyond the teaching assistantship:  CURE leadership as a training platform for future faculty.  J Chem Educ 95, 3-6

145.  Lee SG, Jez JM (2017) Conformational changes in the di-domain structure of Arabidopsis phosphoethanolamine methyltransferase leads to active site formation.  J Biol Chem 292, 21690-702

144.  Damodaran S, Westfall CS, Kisely BA, Jez JM, Subramanian S (2017) Nodule-enriched Gretchen Hagen 3 enzymes have distinct substrate specificities and are important for proper soybean nodule development.  Int J Mol Sci 18, 2547

143.  Kroll K*, Holland CK*, Starks CM, Jez JM (2017) Evolution of allosteric regulation in chorismate mutases from early plants.  Biochem J 474, 3705-17

142.  Negi SS, Schein CH, Ladics GS, Mirsky H, Chang P, Raschle JB, Kough J, Sterck L, Papineni S, Jez JM, Mouries LP, Braun W (2017) Functional classification of protein toxins as a basis for bioinformatic screening.  Sci Rep 7, 13940

141.  Schaal BA, Jez JM (2017) Biodiversity, biotechnology, and the environment.  In Biodiversity and the Law:  Intellectual Property, Biotechnology, and Traditional Knowledge (McManis CR, Ong B, Eds.), pp. 98-108, Earthscan Publishing, London UK 

140.  Hackenberg D, McKain MR, Lee SG, Roy Choudhury S, McCann T, Schreier S, Harkess A, Pires JC, Wong GKS, Jez JM, Kellogg EA, Pandey S (2017) Galpha:RGS protein pairs maintain functional compatibility and conserved interaction interfaces throughout evolution despite frequent loss of RGS proteins in plants.  New Phytologist 216, 562-575

139.  Schenck CA*, Holland CK*, Schneider MR, Men Y, Lee SG, Jez JM, Maeda HA (2017) Molecular basis of the evolution of alternative tyrosine biosynthesis pathways in plants.  Nature Chem Biol 13, 1029-35

138.  Xu A, Liu F, Chen P, Jez JM, Krishnan HB (2017) Beta-N-oxalyl-L-alpha, beta-diaminopropionic acid (beta-ODAP) content in Lathyrus sativus: the integration of nitrogen and sulfur metabolism through beta-cyanoalanine synthase.  Int J Mol Sci 18, 526

137.  Jez JM (2017) Revisiting protein structure, function, and evolution in the genomic era.  J Invert Path 142, 11-5

136.  Cascella B, Lee SG, Singh S, Jez JM, Mirica LM (2017) The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4a/JMJD2A.  Chem Commun 53, 2174-7

135.  Holland CK, Cascella B, Jez JM (2016) Dissonance strikes a chord in stilbene synthesizers.  Cell Chem Biol 23, 1440-1

134.  Jez JM (2016) Lost in translation: the truth behind university-industry collaborations.  Scientific American online.

133.  Westfall CS* Sherp AM*, Zubieta C, Alvarez S, Schraft E, Marcellin R, Ramirez L, Jez JM (2016) Arabidopsis thaliana GH3.5 acyl acid amido synthetase mediates metabolic crosstalk in auxin and salicylic acid homeostasis.  Proc Natl Acad Sci USA 113, 11917-22

132.  Jez JM, Ravilious GE, Herrmann J (2016) Structural biology and regulation of the plant sulfation pathway.  Chem-Biol Interact 259, 31-8

131.  Jez JM, Lee SG, Sherp AM (2016) The next green movement:  plant biology for the environment and sustainability.  Science 353, 1241-4

130.  Machingura M, Salomon E, Jez JM, Ebbs SD (2016) The beta-cyanoalanine synthase pathway: beyond cyanide detoxification.  Plant Cell Environ 39, 2329-41 

129.  Kilgore MB, Holland CK, Jez JM, Kutchan TM (2016) Identification of a noroxomaritidine reductase with Amaryllidaceae alkaloid biosynthesis related activities.  J Biol Chem 291, 16740-52

128.  Lee SG, Nwumeh R, Jez JM (2016) Structure and mechanism of isopropylmalate dehydrogenase from Arabidopsis thaliana: insights on leucine and glucosinolate biosynthesis.  J Biol Chem 291, 13421-30

127.  Korasick DA, Jez JM (2016) Protein domains: structure, function, and methods.  In Encyclopedia of Cell Biology, Vol. 1 (Bradshaw RA & Stahl P, Eds.) pp. 91-7, Academic Press, Waltham, MA

126.  Herrmann J, Nathin D, Lee SG, Sun T, Jez JM (2015) Recapitulating the structural evolution of redox regulation in adenosine-5'-phosphosulfate kinase from cyanobacteria to plants.  J Biol Chem 290, 24705-14

125.  Jez JM (2015) Little green chemists.  The Biologist 62, S10-11

124.  Korasick DA, Jez JM, Strader LC (2015) Refining the nuclear auxin response pathway through structural biology.  Curr Opin Plant Biol 27, 22-8

123.  Cahoon RE, Lutke WK, Cameron JC, Chen S, Lee SG, Rivard RS, Rea PA, Jez JM (2015) Adaptive engineering of phytochelatin-based heavy metal tolerance.  J Biol Chem 290, 17321-30

122.  Bhuiya MW*, Lee SG*, Jez JM, Yu O (2015) Structure and mechanism of ferulic acid decarboxylase (FDC1) from Sacchromyces cerevisiae.  Appl Environ Micro 81, 4216-23

121.  Malik MR, Yang W, Patterson N, Tang J, Wellinghof RL, Preuss ML, Burkitt C, Sharma N, Ji Y, Jez JM, Peoples OP, Jaworski JG, Cahoon EB, Snell KD (2015) Production of high levels of poly-3-hydroxybutyrate in plastids of Camelina sativa seeds.  Plant Biotech J 13, 675-88 

120.  Korasick DA, Chatterjee S, Tonelli M, Dashti H, Lee SG, Westfall CS, Fulton DB, Andreotti AH, Amarasinghe GK, Strader LC, Jez JM (2015) Defining a two-pronged structural model for PB1 domain interaction in plant auxin response.  J Biol Chem 290, 12868-78

119.  Krishnan HB, Jez JM (2014) Challenges and opportunities in the improvement of soybean protein quality.  In Proceedings of SOYCON 2014:  International Soybean Research Conference (Gupta GK and Joshi OP, Eds.), pp. 57-64, Society for Soybean Research, Indore, India

118.  Kim WS, Jez JM, Krishnan HB (2014) Effect of proteome rebalancing and sulfur nutrition on the accumulation of methionine rich delta-zein in transgenic soybean.  Front Plant Sci 6, 633

117.  Saen-oon S*, Lee SG*, Jez JM, Guallar V (2014) An alternate mechanism for the methylation of phosphoethanolamine catalyzed by Plasmodium falciparum phosphoethanolamine methyltransferase.  J Biol Chem 289, 33815-25

116.  Westfall CS, Xu A, Jez JM (2014) Structural evolution of differential amino acid effector regulation in plant chorismate mutases.  J Biol Chem 289, 28619-28

115.  Meesters C, Monig T, Oeljeklaus J, Krahn D, Westfall CS, Hause B, Jez JM, Kaiser M, Kombrink E (2014) A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana.  Nature Chem Biol 10, 830-6

114.  Jez JM, Blankenship RE (2014) Lights, x-rays, oxygen!  Cell 158, 701-3

113.  Lee SG, Krishnan HB, Jez JM (2014) Structural basis for regulation of rhizobial nodulation and symbiosis gene expression by the regulatory protein NolR.  Proc Natl Acad Sci USA 111, 6509-14

112.  Korasick DA, Westfall CS, Lee SG, Nanao M, Dumas R, Hagen G, Guilfoyle TJ, Jez JM, Strader LC (2014) Molecular basis for auxin response factor protein interaction and the control of auxin response repression.  Proc Natl Acad Sci USA 111, 5427-32

111.  Lee SG, Jez JM (2014) Nematode phospholipid metabolism: an example of closing the genome-structure-function circle.  Trends Parasitol 30, 241-50

110.  Herrmann J, Ravilious GE, McKinney SE, Westfall CS, Lee SG, Baraniecka P, Giovannetti M, Kopriva S, Krishnan HB, Jez JM (2014) Structure and mechanism of soybean ATP sulfurylase and the committed step in plant sulfur assimilation.  J Biol Chem 289, 10919-29

109.  Preuss ML, Cameron JC, Berg RH, Jez JM (2014) Immunolocalization of glutathione biosynthesis enzymes in Arabidopsis thaliana.  Plant Physiol Biochem 75, 9-14

108.  Yi H*, Dey S*, Kumaran S, Lee SG, Krishnan HB, Jez JM (2013) Structure of soybean serine acetyltransferase and formation of the cysteine regulatory complex as a molecular chaperone.  J Biol Chem 288, 36463-72

107. Hammond BG, Kough J, Herouet-Guicheney C, Jez JM; ILSI International Food Biotechnology Committee Task Force on the Use of Mammalian Toxicology Studies in the Safety Assessment of GM Foods (2013) Toxicological evaluation of proteins introduced into food crops.  Crit Rev Toxicol 43(S2), 25-42

106. Bartholomaeus A, Parrott W, Bondy G, Walker K; ILSI International Food Biotechnology Committee Task Force** on the Use of Mammalian Toxicology Studies in the Safety Assessment of GM Foods (2013) The use of whole food animal studies in the safety assessment of genetically modified crops: limitations and recommendations.  Crit Rev Toxicol 43(S2), 1-24 - **Group Author

105.  Round A, Brown E, Kapp U, Marcelin R, Westfall CS, Pernot P, Jez JM, Zubieta C (2013) Determination of GH3.12 protein conformation through on-line HPLC-integrated SAXS measurements combined with x-ray crystallography.  Acta Crystallogr D 69, 2072-80

104.  Lee SG, Jez JM (2013) Evolution of structure and mechanistic divergence in di-domain methyltransferases from nematode phosphocholine biosynthesis.  Structure 21, 1778-87

103.  Ravilious GE, Herrmann J, Lee SG, Westfall CS, Jez JM (2013) Kinetic mechanism of a dimeric ATP sulfurylase from plants.  Biosci Rep 33, e00053

102.  Westfall CS, Muehler AM, Jez JM (2013) Enzyme action in the regulation of plant hormone responses.  J Biol Chem 288, 19304-11 

101.  Jez JM, Dey S (2013) The cysteine regulatory complex from plants and microbes:  what was old is new again.  Curr Opin Struct Biol 23, 302-10

100.  Steiner HY, Halpin C, Jez JM, Kough J, Parrott W, Underhill L, Weber N, Hannah LC (2013) Evaluating the potential for adverse interactions within genetically engineered breeding stacks.  Plant Physiol 161, 1587-94

99.  Ravilious GE, Westfall CS, Jez JM (2013) Redox-linked gating of nucleotide binding by the N-terminal domain of adenosine 5'-phosphosulfate kinase.  J Biol Chem 288, 6107-15

98.  Musgrave WB, Yi H, Kline D, Cameron JC, Wignes J, Dey S, Pakrasi HB, Jez JM (2013) Probing the origins of glutathione biosynthesis through biochemical analysis of glutamate-cysteine ligase and glutathione synthetase from a model photosynthetic prokaryote.  Biochem J 450, 63-72

97.  Weber N, Halpin C, Hannah LC, Jez JM, Kough J, Parrott W (2012) Crop genome plasticity and its relevance to food and feed safety of genetically engineered breeding stacks.  Plant Physiol 160, 1842-53

96.  Zhang M, Ravilious GE, Hicks LM, Jez JM, McCulla R (2012) Redox switching of adenosine-5'-phosphosulfate kinase with photoactivatable atomic oxygen precursors.  J Am Chem Soc 134, 16979-82

95.  Yi H, Jez JM (2012) Assessing functional diversity in the soybean beta-substituted alanine synthase enzyme family.  Phytochemistry 83, 15-24

94.  Ravilious GE, Jez JM (2012) Structural biology of plant sulfur metabolism:  from assimilation to biosynthesis.  Nat Prod Rep 29, 1138-52

93.  Parrott WA, Jez JM, Hannah LC (2012) To be or not to be transgenic.  Nature Biotech 30, 825-6

92.  Lallemand A, Zubieta C, Lee SG, Wang Y, Acajjaoui S, Timmins J, McSweeney S, Jez JM, McCarthy JG, McCarthy AA (2012) Structural basis for the biosynthesis of the major chlorogenic acids found in coffee.  Plant Physiol 160, 249-60

91.  Ravilious GE, Jez JM (2012) Nucleotide binding site communication in Arabidopsis thaliana adenosine 5'-phosphosulfate kinase.  J Biol Chem 287, 30385-94

90.  Yi H, Juergens M, Jez JM (2012) Structure of soybean beta-cyanoalanine synthase and the molecular basis for cyanide detoxification in plants.  Plant Cell 24, 2696-706

89.  Lee SG, Alpert TD, Jez JM (2012) Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine.  Bioorg Med Chem Lett 22, 4990-3

88.  Westfall CS*, Zubieta C*, Herrmann J, Kapp U, Nanao MH, Jez JM (2012) Structural basis for pre-receptor modulation of plant hormones by GH3 family proteins.  Science 336, 1708-11

87.  Roy Choudhury S, Westfall CS, Laborde JP, Bisht NC, Jez JM, Pandey S (2012) Two chimeric regulator of G-protein signaling (RGS) proteins differentially modulate soybean heterotrimeric G-protein cycle.  J Biol Chem 287, 17870-81

86.  Galant A, Koester RP, Ainsworth EA, Hicks LM, Jez JM (2012)  From climate change to molecular response:  redox-proteomics of ozone-induced responses in soybean.  New Phytologist 194, 220-9

85.  Lee SG, Kim YC, Alpert TD, Nagata A, Jez JM (2012) Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum - an anti-parasitic drug target.  J Biol Chem 287, 1426-34

84.  Ravilious GE, Nguyen A, Francois JA, Jez JM (2012) Structural basis and evolution of redox regulation in plant adenosine-5'-phosphosulfate kinase.  Proc Natl Acad Sci USA 109, 309-14

83.  Kim WS, Chronis D, Juergens M, Schroeder AC, Hyun SW, Jez JM, Krishnan HB (2012) Transgenic soybean plants overexpressing O-acetylserine sulfhydrylase accumulate enhanced levels of cysteine and Bowman-Birk protease inhibitor in seeds. Planta 235, 13-23

82.  Hasnain G, Waller JC, Alvarez S, Ravilious GE, Jez JM, Hanson AD (2012) Mutational analysis of YgfZ, a folate-dependent protein implicated in iron/sulfur cluster metabolism.  FEMS Microbiol Lett 326, 168-72

81.   Wang Y*, Yi H*, Wang M, Yu O, Jez JM (2011) Structural and kinetic analysis of the unnatural fusion protein 4-coumaroyl-CoA ligase:stilbene synthase.  J Am Chem Soc 133, 20684-7

80.  Lee SG, Haakenson W, McCarter JP, Williams DJ, Hresko MC, Jez JM (2011) Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode Haemonchus contortusJ Biol Chem 286, 38060-8

79.  Hardaluk L, Preuss ML, Jez JM (2011)  Sulfur metabolism as a support system for plant heavy metal tolerance In Detoxification of Heavy Metals (Sheramenti I and Varma A, Eds.), pp. 289-302, Springer-Verlag, NY

78.  Galant A, Preuss ML, Cameron J, Jez JM (2011) Plant glutathione biosynthesis - diversity in biochemical regulation and reaction products.  Frontiers Plant Sci 2, 45

77.  Lee SG, Jez JM (2011) The phosphobase methylation pathway in Caernorhabditis elegans: a new route to phospholipids in animals.  Curr Chem Biol 5, 183-8

76.  He Y, Galant A, Pang Q, Strul JM, Balogun S, Jez JM, Chen S (2011) Structural and functional evolution of isopropylmalate dehydrogenases in the leucine and glucosinolate pathways of Arabidopsis thalianaJ Biol Chem 286, 28794-801

75.  Jez JM (2011) Toward protein engineering for phytoremediation:  possibilities and challenges.  Int J Phytoremediation 13, S77-89

74.  Alvarez S*, Galant A*, Jez JM, Hicks LM (2011) Redox-regulatory mechanisms induced by oxidative stress in Brassica juncea roots monitored by 2-DE proteomics.  Proteomics 11, 1346-50

73.  Hammond BG, Jez JM (2011) Impact of food processing on the dietary risk assessment of proteins introduced into biotechnology-derived soybean and corn crops.  Food Chem Toxicol 49, 711-21

72.  Bisht N, Jez JM, Pandey S (2011) An elaborate heterotrimeric G-protein family from soybean expands the diversity of plant G-protein networks.  New Phytologist 190, 35-48

71.  Shin R, Jez JM, Basra A, Zhang B, Schachtman DP (2011)  14-3-3 Proteins fine-tune plant nutrient metabolism.  FEBS Lett 585, 143-7

70.  Westfall CS, Herrmann J, Chen Q, Wang S, Jez JM (2010) Modulating plant hormone levels by enzyme action:  the GH3 family of acyl acid amido synthetases.  Plant Signal Behav 5, 1597-602

69.  Yi H, Ravilious GE, Galant A, Krishnan HB, Jez JM (2010) Thiol metabolism in soybean: sulfur to homoglutathione.  Amino Acids 39, 963-78

68.  Chen Q, Westfall CS, Hicks LM, Wang S, Jez JM (2010) Kinetic basis for the conjugation of auxin by a GH3 family indole acetic acid-amido synthetase.  J Biol Chem 285, 29780-6

67.  Yi H, Galant A, Ravilious GE, Preuss ML, Jez JM (2010) Sensing sulfur conditions:  simple to complex biochemical regulatory mechanisms in plant thiol metabolism.  Mol Plant 3, 269-79

66.  Higashi Y, Smith TJ, Jez JM, Kutchan TM (2010) Crystallization and preliminary x-ray diffraction analysis of salutaridine reductase from the opium poppy Papaver somniferumActa Cryst F 66, 163-6

65.  Schroeder AC*, Zhu C*, Yanamadala SR*, Cahoon RE, Arkus KAJ, Wachsstock L, Bleeke J, Krishnan HB, Jez JM (2010) Threonine-insensitive homoserine dehydrogenase from soybean: genomic organization, kinetic characterization, and in vivo activity.  J Biol Chem 285, 827-34

64.  Galant A, Arkus KAJ, Zubieta C, Cahoon RE, Jez JM (2009) Structural basis for evolution of product diversity in soybean glutathione synthesis.  Plant Cell 21, 3450-8

63.  He Y, Mawhinney TP, Preuss ML, Schroeder AC, Chen B, Abraham L, Jez JM, Chen S (2009) A redox active isopropylmalate dehydrogenase functions in the biosynthesis of glucosinolates and leucine in Arabidopsis.  Plant J 60, 679-90

62.  Chen Q, Zhang B, Hicks LM, Wang S, Jez JM (2009) A liquid chromatography-tandem mass spectrometry-based assay for indole-3-acetic acid-amido synthetases.  Anal Biochem 390, 149-54

61.  Jez JM, Krishnan HB (2009) Sulfur assimilation and cysteine biosynthesis in soybean seeds:  towards engineering sulfur amino acid content In Modification of Seed Composition to Promote Health and Nutrition (Krishnan HB, Ed.), pp. 249-62, ASA-CSSA-SSSA Publishing, Madison, WI

60.  Alvarez S, Berla BM, Sheffield J, Cahoon RE, Jez JM, Hicks LM  (2009) Comprehensive analysis of the Brassica juncea root proteome in response to cadmium exposure by complementary proteomic approaches.  Proteomics 9, 2419-31

59.  Yi H, Preuss ML, Jez JM (2009) The devil (and an active jasmonate hormone) are in the details.  Nature Chem Biol  5, 273-4

58.  Kumaran S, Yi H, Krishnan HB, Jez JM (2009) Assembly of the cysteine synthase complex and the regulatory role of protein-protein interactions.  J Biol Chem  284, 10268-75


Donald Danforth Plant Science Center (2002-2010)

57.  Jez JM, Fukagawa NK (2008) Plant sulfur compounds and human health In Sulfur: A Missing Link Between Soils, Crops, and Nutrition (Jez JM, Ed.) pp. 281-92, ASA-CSSA-SSSA Publishing, Madison, WI

56.  Yu O, Jez JM (2008) Nature’s assembly line:  biosynthesis of simple phenylpropanoids and plant polyketides.  Plant J 54, 750-62

55.  Schroeder AC*, Kumaran S*, Hicks LM, Cahoon RE, Halls C, Yu O, Jez JM (2008) Contributions of conserved serine and tyrosine residues to catalysis, ligand binding, and cofactor processing in the active site of tyrosine ammonia lyase.  Phytochemistry 69, 1496-506

54.  Arkus KAJ, Jez JM (2008) An integrated protein chemistry lab module: choloropyll and chlorophyllase.  Biochem Mol Biol Educ 36, 125-8

53.  Zubieta C, Arkus KAJ, Cahoon RE, Jez JM  (2008) A single amino acid change is responsible for evolution of acyltransferase specificity in bacterial methionine biosynthesis.  J Biol Chem  283, 7561-7

52.  Kumaran S, Francois JA, Krishnan HB, Jez JM  (2008) Regulatory protein-protein interactions in primary metabolism: the case of the cysteine synthase complex In Sulfur Assimilation and Abiotic Stress in Plants (NA Khan, RP Singh, Eds), pp. 97-109, Springer-Verlag, NY

51.  Phartiyal P, Kim WS, Cahoon RE, Jez JM, Krishnan HB (2008) The role of 5’-adenylylsulfate reductase in the sulfur assimilation pathway of soybean:  molecular cloning, gene expression, and kinetic characterization.  Phytochemistry  69, 356-64

50.  Jez JM, Schachtman DP, Berg RH, Taylor CG, Chen S, Hicks LM, Jaworski JG, Smith TJ, Nielsen E, Pikaard CS (2007) Developing a new interdisciplinary lab course for undergraduate and graduate students: plant cells and proteins.  Biochem Mol Biol Educ 35, 410-5

49.  Hicks LM, Cahoon RE, Bonner ER, Rivard RS, Sheffield J, Jez JM (2007) Thiol-based regulation of redox-active glutamate-cysteine ligase from Arabidopsis thalianaPlant Cell  19, 2653-61

48.  Herrera K, Cahoon RE, Kumaran S, Jez JM (2007) Reaction mechanism of glutathione synthetase from Arabidopsis thaliana: site-directed mutagenesis of active site residues.  J Biol Chem  282, 17157-65

47. Fu CJ, Jez JM, Kerley MS, Allee GL, Krishnan HB (2007) Identification, characterization, epitope mapping, and three-dimensional modeling of alpha-subunit of beta-conglycinin of soybean, a potential allergen for young pigs.  J Agric Food Chem 55, 4014-20

46.  Kumaran S, Jez JM (2007) Thermodynamics of the interaction between O-acetylserine sulfhydrylase and the C-terminus of serine acetyltransferase. Biochemistry 46, 5586-94

45.  Shin R, Alvarez S, Burch AY, Jez JM, Schachtman DP (2007) Phosphoproteomic identification of targets of the Arabidopsis sucrose nonfermenting-like kinase SnRK2.8 reveals a connection to metabolic processes.  Proc Natl Acad Sci USA 104, 6460-5

44.  Brendza KM, Haakenson W, Cahoon RE, Hicks LM, Palavalli LH, Chiapelli B, McLaird M, McCarter JP, Williams DJ, Hresko MC, Jez JM (2007) Phosphoethanolamine N-methyltransferase (PMT-1) catalyzes the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans.  Biochem  J 404, 439-48

43. Jez JM (2007) Phosphatidylcholine biosynthesis as a potential target for inhibition of metabolism in parasitic nematodes.  Curr Enz Inhib 3, 133-42

42. Francois JA*, Kumaran S*, Jez JM (2006) Structural basis for interaction of O-acetylserine sulfhydrylase and serine acetyltransferase in the Arabidopsis cysteine synthase complex.  Plant Cell  18, 3647-55

41. Zhang Y, Li SZ, Pan X, Cahoon RE, Jaworski JG, Wang X, Jez JM, Chen F, Yu O (2006) Using unnatural protein fusions to engineer resveratrol biosynthesis in yeast and mammalian cells.  J Am Chem Soc 128, 13030-1

40. Romanyuk ND*, Rigden DJ*, Vatamaniuk OK*, Lang A, Cahoon RE, Jez JM, Rea PA (2006) Mutagenic definition of papain-like catalytic triad and sufficiency of N-terminal domain for single-site enzyme acylation and core catalysis by an eukaryotic phytochelatin synthase.  Plant Physiol 141, 858-69

39. Phartiyal P, Kim WS, Cahoon RE, Jez JM, Krishnan HB (2006) Soybean ATP sulfurylase, a homodimeric enzyme involved in sulfur assimilation, is abundantly expressed in roots and induced by cold treatment.  Arch Biochem Biophys 450, 20-9

38. Palavalli LH*, Brendza KM*, Haakenson W, Cahoon RE, McLaird M, Hicks LM, McCarter JP, Williams DJ, Hresko MC, Jez JM (2006) Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis.  Biochemistry 45, 6056-65

37. Arkus KAJ, Jez JM (2006) Development of a high-throughput purification method and a continuous assay for chlorophyllase.  Anal Biochem 353, 93-8

36. Bonner ER, Cahoon RE, Knapke SM, Jez JM (2005) Molecular basis of plant cysteine biosynthesis: structural and functional analysis of O-acetylserine sulfhydrylase from Arabidopsis thalianaJ Biol Chem 280, 38803-13

35. Arkus KAJ, Cahoon EB, Jez JM (2005) Mechanistic analysis of wheat chlorophyllase.  Arch Biochem Biophys 438, 146-55

34. Jez JM, Cahoon RE (2004) Kinetic mechanism of glutathione synthetase from Arabidopsis thaliana.  J Biol Chem 279, 42726-31

33. Jez JM, Cahoon RE, Chen S (2004) Arabidopsis thaliana glutamate-cysteine ligase: functional properties, kinetic mechanism, and regulation of activity.  J Biol Chem 279, 33463-70


Kosan Biosciences, Inc. (2001-2002)

32.  Jez JM, Chen JC, Rastelli J, Stroud RM, Santi DV (2003) Crystal structure and molecular modeling of 17-DMAG in complex with the N-terminal domain of human hsp90.  Chem Biol 10, 361-8


Post-doc - Salk Institute (1998-2001)

31.  Jez JM, Bowman ME, Noel JP  (2002) Expanding the biosynthetic repertoire of type III polyketide synthases by altering starter molecule specificity.  Proc Natl Acad Sci USA 99, 5319-24

30.  Jez JM, Bowman ME, Noel JP  (2002) The role of hydrogen bonds in the reaction mechanism of chalcone isomerase.  Biochemistry 41, 5168-76

29.  Jez JM, Noel JP  (2002) Reaction mechanism of chalcone isomerase: pH-dependence, diffusion control, and product binding differences.  J Biol Chem  277, 1361-9

28.  Noel JP, Jez JM, Austin MB, Bowman ME, Ferrer JL (2002) Structurally guided alteration of biosynthesis in plant type III polyketide synthases in Recent Advances in Phytochemistry Vol. 36 – Phytochemistry in the Genomics and Post-Genomics Era (JT Romeo, Ed.)  pp. 197-222, Plenum Press, New York

27.  Jez JM, Ferrer JL, Bowman ME, Austin MB, Schröder J, Dixon RA, Noel JP  (2001) Structure and mechanism of chalcone synthase-like polyketide synthases.  J Ind Micro Biotech  27, 393-8

26.  Jez JM, Bowman ME, Noel JP  (2001) Structure-guided programming of polyketide chain-length determination in chalcone synthase.  Biochemistry 49, 14829-38

25.  Mallis RJ, Bruzin K, Jez JM, Wilson EK, Dieckmann GR, Robic S, Harrahy J  (2001) Proteins: the complete works.  Trends Biochem Sci  26, 642-3

24.  Penning TM, Jez JM  (2001) Enzyme redesign.  Chem Rev 101, 3027-46

23.  Jez JM, Noel JP  (2000) Mechanism of chalcone synthase:  pKa of the catalytic cysteine and the role of the conserved histidine in a plant-specific polyketide synthase.  J Biol Chem  275, 39640-6

22.  Jez JM, Austin MB, Ferrer J-L, Bowman ME, Schröder J, Noel JP  (2000) Structural control of polyketide formation in plant-specific polyketide synthases.  Chem Biol 7, 919-30

21.  Jez JM, Bowman ME, Dixon RA, Noel JP  (2000) Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase.  Nature Struct Biol 7, 786-91

20.  Jez JM, Noel JP  (2000) A kaleidoscope of carotenoids.  Nature Biotech 18, 825-6

19.  Jez JM, Ferrer J-L, Bowman ME, Dixon RA, Noel JP  (2000) Dissection of malonyl-CoA decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase.  Biochemistry 39, 890-902

18.  Ferrer J-L, Jez JM, Bowman ME, Dixon RA, Noel JP  (1999) Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis.  Nature Struct Biol  6, 775-84


Graduate School - University of Pennsylvania (1992-1998)

17.  Penning TM, Ma H, Jez JM  (2001) Engineering steroid hormone specificity into aldo-keto reductases.  Chem-Biol Interact 130-132, 659-71

16.  Jez JM, Penning TM  (2001) The aldo-keto reductase superfamily:  an update.  Chem-Biol Interact 130-132, 499-525

15.  Penning TM, Burczynski ME, Jez JM, Lin H-K, Ma H, Moore M, Ratnam K, Palackal N (2001) Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).  Mol Cell Endocrinol  171, 137-49

14.  Penning TM, Burczynski ME, Jez JM, Hung C-F, Lin H-K, Ma H, Moore M, Palackal N, Ratnam K  (2000) Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation sex hormones.  Biochem J 351, 67-77

13.  Jez JM, Penning TM  (1998) Engineering steroid 5beta-reductase activity into rat liver 3alpha-hydroxysteroid dehydrogenase.  Biochemistry 37, 9695-703

12.  Schlegel BP, Jez JM, Penning TM  (1998) Mutagenesis of 3alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases.  Biochemistry   37, 3538-48

11.  Penning TM, Lin H-K, Jez JM, Ricigliano JW  (1997) Inhibition of type 3 3alpha-hydroxysteroid dehydrogenase in Emerging Therapeutic Targets, Vol. 1: Oncologic, Endocrine, & Metabolic (A Ward, Ed.)  pp.  141-5, Ashley Publications Ltd., London

10.  Jez JM*, Lin H-K*, Schlegel BP, Peehl DM, Pachter JA, Penning TM  (1997) Expression and characterization of recombinant type 2 3alpha-hydroxysteroid dehydrogenase from human prostate:  Demonstration of bifunctional 3alpha/17beta-HSD activity and cellular distribution.  Mol Endocrinol 11, 1971-84

9.  Jez JM, Flynn TG, Penning TM  (1997) A new nomenclature for the aldo-keto reductase superfamily.  Biochem Pharmacol  54, 639-47

8.  Jez JM, Bennett MJ, Schlegel BP, Lewis M, Penning TM  (1997) Comparative anatomy of the aldo-keto reductase superfamily.  Biochem J  326, 625-36

7.  Bennett MJ, Albert RH, Jez JM, Ma H, Penning TM, Lewis M  (1997) Steroid recognition and regulation of hormone action:  structure of testosterone and NADP+ bound to 3alpha-hydroxysteroid/dihydrodiol dehydrogenase.  Structure 5, 799-812

6.  Penning TM, Bennett MJ, Smith-Hoog S, Schlegel BP, Jez JM, Lewis M  (1997) Structure and function of rat 3alpha-hydroxysteroid dehydrogenase.  Steroids 62, 101-11

5.  Jez JM, Flynn TG, Penning TM  (1996) A proposed nomenclature system for the aldo-keto reductase superfamily in Enzymology and Molecular Biology of Carbonyl Metabolism 6 (H Weiner, R Lindahl, DW Crabb, & TG Flynn, Eds.)  pp. 579-89, Plenum Press, New York

4.  Jez JM, Schlegel BP, Penning TM  (1996) Characterization of the substrate binding pocket in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase:  the roles of tryptophans in ligand recognition and protein fluorescence.  J Biol Chem 271, 30190-8

3.  Bennett MJ, Schlegel BP, Jez JM, Penning TM, Lewis M  (1996) Structure of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+.  Biochemistry 35, 10702-11

2.  Penning TM, Pawlowski JE, Schlegel BP, Jez JM, Lin H-K, Hoog SS, Bennett MJ, Lewis M  (1996) Mammalian 3alpha-hydroxysteroid dehydrogenases.  Steroids 61, 508-23

1.  Jez JM, Vanderkooi JM, Laties AM  (1996) Spectroscopic characterization of bendazac and benzydamine:  possible photochemical modes of action.  Biochem Biophys Res Comm  221, 266-70