Washington University (2008-present)
103. Ravilious GE, Herrmann J, Lee SG, Westfall CS, Jez JM (2013) Kinetic mechanism of a dimeric ATP sulfurylase from plants. Biosci Rep (submitted)
102. Westfall CS, Muehler AM, Jez JM (2013) Enzyme action in the regulation of plant hormone responses. J Biol Chem (in press)
101. Jez JM, Dey S (2013) The cysteine regulatory complex from plants and microbes: what was old is new again. Curr Opin Struct Biol 23, 302-10
100. Steiner HY, Halpin C, Jez JM, Kough J, Parrott W, Underhill L, Weber N, Hannah LC (2013) Evaluating the potential for adverse interactions within genetically engineered breeding stacks. Plant Physiol 161, 1587-94
99. Ravilious GE, Westfall CS, Jez JM (2013) Redox-linked gating of nucleotide binding by the N-terminal domain of adenosine 5'-phosphosulfate kinase. J Biol Chem 288, 6107-15
98. Musgrave WB, Yi H, Kline D, Cameron JC, Wignes J, Dey S, Pakrasi HB, Jez JM (2013) Probing the origins of glutathione biosynthesis through biochemical analysis of glutamate-cysteine ligase and glutathione synthetase from a model photosynthetic prokaryote. Biochem J 450, 63-72
97. Weber N, Halpin C, Hannah LC, Jez JM, Kough J, Parrott W (2012) Crop genome plasticity and its relevance to food and feed safety of genetically engineered breeding stacks. Plant Physiol 160, 1842-53
96. Zhang M, Ravilious GE, Hicks LM, Jez JM, McCulla R (2012) Redox switching of adenosine-5'-phosphosulfate kinase with photoactivatable atomic oxygen precursors. J Am Chem Soc 134, 16979-82
95. Yi H, Jez JM (2012) Assessing functional diversity in the soybean beta-substituted alanine synthase enzyme family. Phytochemistry 83, 15-24
94. Ravilious GE, Jez JM (2012) Structural biology of plant sulfur metabolism: from assimilation to biosynthesis. Nat Prod Rep 29, 1138-52
93. Parrott WA, Jez JM, Hannah LC (2012) To be or not to be transgenic. Nature Biotech 30, 825-6
92. Lallemand A, Zubieta C, Lee SG, Wang Y, Acajjaoui S, Timmins J, McSweeney S, Jez JM, McCarthy JG, McCarthy AA (2012) Structural basis for the biosynthesis of the major chlorogenic acids found in coffee. Plant Physiol 160, 249-60
91. Ravilious GE, Jez JM (2012) Nucleotide binding site communication in Arabidopsis thaliana adenosine 5'-phosphosulfate kinase. J Biol Chem 287, 30385-94
90. Yi H, Juergens M, Jez JM (2012) Structure of soybean beta-cyanoalanine synthase and the molecular basis for cyanide detoxification in plants. Plant Cell 24, 2696-706
89. Lee SG, Alpert TD, Jez JM (2012) Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine. Bioorg Med Chem Lett 22, 4990-3
88. Westfall CS*, Zubieta C*, Herrmann J, Kapp U, Nanao MH, Jez JM (2012) Structural basis for pre-receptor modulation of plant hormones by GH3 family proteins. Science 336, 1708-11 (*equal contribution)
87. Roy Choudhury S, Westfall CS, Laborde JP, Bisht NC, Jez JM, Pandey S (2012) Two chimeric regulator of G-protein signaling (RGS) proteins differentially modulate soybean heterotrimeric G-protein cycle. J Biol Chem 287, 17870-81
86. Galant A, Koester RP, Ainsworth EA, Hicks LM, Jez JM (2012) From climate change to molecular response: redox-proteomics of ozone-induced responses in soybean. New Phytologist 194, 220-9
85. Lee SG, Kim YC, Alpert TD, Nagata A, Jez JM (2012) Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum - an anti-parasitic drug target. J Biol Chem 287, 1426-34
84. Ravilious GE, Nguyen A, Francois JA, Jez JM (2012) Structural basis and evolution of redox regulation in plant adenosine-5'-phosphosulfate kinase. Proc Natl Acad Sci USA 109, 309-14
83. Kim WS, Chronis D, Juergens M, Schroeder AC, Hyun SW, Jez JM, Krishnan HB (2012) Transgenic soybean plants overexpressing O-acetylserine sulfhydrylase accumulate enhanced levels of cysteine and Bowman-Birk protease inhibitor in seeds. Planta 235, 13-23
82. Hasnain G, Waller JC, Alvarez S, Ravilious GE, Jez JM, Hanson AD (2012) Mutational analysis of YgfZ, a folate-dependent protein implicated in iron/sulfur cluster metabolism. FEMS Microbiol Lett 326, 168-72
81. Wang Y*, Yi H*, Wang M, Yu O, Jez JM (2011) Structural and kinetic analysis of the unnatural fusion protein 4-coumaroyl-CoA ligase:stilbene synthase. J Am Chem Soc 133, 20684-7 (*equal contribution)
80. Lee SG, Haakenson W, McCarter JP, Williams DJ, Hresko MC, Jez JM (2011) Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode Haemonchus contortus. J Biol Chem 286, 38060-8
79. Hardaluk L, Preuss ML, Jez JM (2011) Sulfur metabolism as a support system for plant heavy metal tolerance In Detoxification of Heavy Metals (Sheramenti I and Varma A, Eds.), pp. 289-302, Springer-Verlag, NY
78. Galant A, Preuss ML, Cameron J, Jez JM (2011) Plant glutathione biosynthesis - diversity in biochemical regulation and reaction products. Frontiers Plant Sci 2, 45
77. Lee SG, Jez JM (2011) The phosphobase methylation pathway in Caernorhabditis elegans: a new route to phospholipids in animals. Curr Chem Biol 5, 183-8
76. He Y, Galant A, Pang Q, Strul JM, Balogun S, Jez JM, Chen S (2011) Structural and functional evolution of isopropylmalate dehydrogenases in the leucine and glucosinolate pathways of Arabidopsis thaliana. J Biol Chem 286, 28794-801
75. Jez JM (2011) Toward protein engineering for phytoremediation: possibilities and challenges. Int J Phytoremediation 13, S77-89
74. Alvarez S*, Galant A*, Jez JM, Hicks LM (2011) Redox-regulatory mechanisms induced by oxidative stress in Brassica juncea roots monitored by 2-DE proteomics. Proteomics 11, 1346-50 (*equal contribution)
73. Hammond BG, Jez JM (2011) Impact of food processing on the dietary risk assessment of proteins introduced into biotechnology-derived soybean and corn crops. Food Chem Toxicol 49, 711-21
72. Bisht N, Jez JM, Pandey S (2011) An elaborate heterotrimeric G-protein family from soybean expands the diversity of plant G-protein networks. New Phytologist 190, 35-48
71. Shin R, Jez JM, Basra A, Zhang B, Schachtman DP (2011) 14-3-3 Proteins fine-tune plant nutrient metabolism. FEBS Lett 585, 143-7
70. Westfall CS, Herrmann J, Chen Q, Wang S, Jez JM (2010) Modulating plant hormone levels by enzyme action: the GH3 family of acyl acid amido synthetases. Plant Signal Behav 5, 1597-602
69. Yi H, Ravilious GE, Galant A, Krishnan HB, Jez JM (2010) Thiol metabolism in soybean: sulfur to homoglutathione. Amino Acids 39, 963-78
68. Chen Q, Westfall CS, Hicks LM, Wang S, Jez JM (2010) Kinetic basis for the conjugation of auxin by a GH3 family indole acetic acid-amido synthetase. J Biol Chem 285, 29780-6
67. Yi H, Galant A, Ravilious GE, Preuss ML, Jez JM (2010) Sensing sulfur conditions: simple to complex biochemical regulatory mechanisms in plant thiol metabolism. Mol Plant 3, 269-79
66. Higashi Y, Smith TJ, Jez JM, Kutchan TM (2010) Crystallization and preliminary x-ray diffraction analysis of salutaridine reductase from the opium poppy Papaver somniferum. Acta Cryst F 66, 163-6
65. Schroeder AC*, Zhu C*, Yanamadala SR*, Cahoon RE, Arkus KAJ, Wachsstock L, Bleeke J, Krishnan HB, Jez JM (2010) Threonine-insensitive homoserine dehydrogenase from soybean: genomic organization, kinetic characterization, and in vivo activity. J Biol Chem 285, 827-34 (*equal contribution)
64. Galant A, Arkus KAJ, Zubieta C, Cahoon RE, Jez JM (2009) Structural basis for evolution of product diversity in soybean glutathione synthesis. Plant Cell 21, 3450-8
63. He Y, Mawhinney TP, Preuss ML, Schroeder AC, Chen B, Abraham L, Jez JM, Chen S (2009) A redox active isopropylmalate dehydrogenase functions in the biosynthesis of glucosinolates and leucine in Arabidopsis. Plant J 60, 679-90
62. Chen Q, Zhang B, Hicks LM, Wang S, Jez JM (2009) A liquid chromatography-tandem mass spectrometry-based assay for indole-3-acetic acid-amido synthetases. Anal Biochem 390, 149-54
61. Jez JM, Krishnan HB (2009) Sulfur assimilation and cysteine biosynthesis in soybean seeds: towards engineering sulfur amino acid content In Modification of Seed Composition to Promote Health and Nutrition (Krishnan HB, Ed.), pp. 249-62, ASA-CSSA-SSSA Publishing, Madison, WI
60. Alvarez S, Berla BM, Sheffield J, Cahoon RE, Jez JM, Hicks LM (2009) Comprehensive analysis of the Brassica juncea root proteome in response to cadmium exposure by complementary proteomic approaches. Proteomics 9, 2419-31
59. Yi H, Preuss ML, Jez JM (2009) The devil (and an active jasmonate hormone) are in the details. Nature Chem Biol 5, 273-4
58. Kumaran S, Yi H, Krishnan HB, Jez JM (2009) Assembly of the cysteine synthase complex and the regulatory role of protein-protein interactions. J Biol Chem 284, 10268-75
Donald Danforth Plant Science Center (2002-2010)
57. Jez JM, Fukagawa NK (2008) Plant sulfur compounds and human health In Sulfur: A Missing Link Between Soils, Crops, and Nutrition (Jez JM, Ed.) pp. 281-92, ASA-CSSA-SSSA Publishing, Madison, WI
56. Yu O, Jez JM (2008) Nature’s assembly line: biosynthesis of simple phenylpropanoids and plant polyketides. Plant J 54, 750-62
55. Schroeder AC, Kumaran S, Hicks LM, Cahoon RE, Halls C, Yu O, Jez JM (2008) Contributions of conserved serine and tyrosine residues to catalysis, ligand binding, and cofactor processing in the active site of tyrosine ammonia lyase. Phytochemistry 69, 1496-506
54. Arkus KAJ, Jez JM (2008) An integrated protein chemistry lab module: choloropyll and chlorophyllase. Biochem Mol Biol Educ 36, 125-8
53. Zubieta C, Arkus KAJ, Cahoon RE, Jez JM (2008) A single amino acid change is responsible for evolution of acyltransferase specificity in bacterial methionine biosynthesis. J Biol Chem 283, 7561-7
52. Kumaran S, Francois JA, Krishnan HB, Jez JM (2008) Regulatory protein-protein interactions in primary metabolism: the case of the cysteine synthase complex In Sulfur Assimilation and Abiotic Stress in Plants (NA Khan, RP Singh, Eds), pp. 97-109, Springer-Verlag, NY
51. Phartiyal P, Kim WS, Cahoon RE, Jez JM, Krishnan HB (2008) The role of 5’-adenylylsulfate reductase in the sulfur assimilation pathway of soybean: molecular cloning, gene expression, and kinetic characterization. Phytochemistry 69, 356-64
50. Jez JM, Schachtman DP, Berg RH, Taylor CG, Chen S, Hicks LM, Jaworski JG, Smith TJ, Nielsen E, Pikaard CS (2007) Developing a new interdisciplinary lab course for undergraduate and graduate students: plant cells and proteins. Biochem Mol Biol Educ 35, 410-5
49. Hicks LM, Cahoon RE, Bonner ER, Rivard RS, Sheffield J, Jez JM (2007) Thiol-based regulation of redox-active glutamate-cysteine ligase from Arabidopsis thaliana. Plant Cell 19, 2653-61
48. Herrera K, Cahoon RE, Kumaran S, Jez JM (2007) Reaction mechanism of glutathione synthetase from Arabidopsis thaliana: site-directed mutagenesis of active site residues. J Biol Chem 282, 17157-65
47. Fu CJ, Jez JM, Kerley MS, Allee GL, Krishnan HB (2007) Identification, characterization, epitope mapping, and three-dimensional modeling of alpha-subunit of beta-conglycinin of soybean, a potential allergen for young pigs. J Agric Food Chem 55, 4014-20
46. Kumaran S, Jez JM (2007) Thermodynamics of the interaction between O-acetylserine sulfhydrylase and the C-terminus of serine acetyltransferase. Biochemistry 46, 5586-94
45. Shin R, Alvarez S, Burch AY, Jez JM, Schachtman DP (2007) Phosphoproteomic identification of targets of the Arabidopsis sucrose nonfermenting-like kinase SnRK2.8 reveals a connection to metabolic processes. Proc Natl Acad Sci USA 104, 6460-5
44. Brendza KM, Haakenson W, Cahoon RE, Hicks LM, Palavalli LH, Chiapelli B, McLaird M, McCarter JP, Williams DJ, Hresko MC, Jez JM (2007) Phosphoethanolamine N-methyltransferase (PMT-1) catalyzes the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans. Biochem J 404, 439-48
43. Jez JM (2007) Phosphatidylcholine biosynthesis as a potential target for inhibition of metabolism in parasitic nematodes. Curr Enz Inhib 3, 133-42
42. Francois JA*, Kumaran S*, Jez JM (2006) Structural basis for interaction of O-acetylserine sulfhydrylase and serine acetyltransferase in the Arabidopsis cysteine synthase complex. Plant Cell 18, 3647-55 (*equal contribution)
41. Zhang Y, Li SZ, Pan X, Cahoon RE, Jaworski JG, Wang X, Jez JM, Chen F, Yu O (2006) Using unnatural protein fusions to engineer resveratrol biosynthesis in yeast and mammalian cells. J Am Chem Soc 128, 13030-1
40. Romanyuk ND*, Rigden DJ*, Vatamaniuk OK*, Lang A, Cahoon RE, Jez JM, Rea PA (2006) Mutagenic definition of papain-like catalytic triad and sufficiency of N-terminal domain for single-site enzyme acylation and core catalysis by an eukaryotic phytochelatin synthase. Plant Physiol 141, 858-69 (*equal contribution)
39. Phartiyal P, Kim WS, Cahoon RE, Jez JM, Krishnan HB (2006) Soybean ATP sulfurylase, a homodimeric enzyme involved in sulfur assimilation, is abundantly expressed in roots and induced by cold treatment. Arch Biochem Biophys 450, 20-9
38. Palavalli LH*, Brendza KM*, Haakenson W, Cahoon RE, McLaird M, Hicks LM, McCarter JP, Williams DJ, Hresko MC, Jez JM (2006) Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis. Biochemistry 45, 6056-65 (*equal contribution)
37. Arkus KAJ, Jez JM (2006) Development of a high-throughput purification method and a continuous assay for chlorophyllase. Anal Biochem 353, 93-8
36. Bonner ER, Cahoon RE, Knapke SM, Jez JM (2005) Molecular basis of plant cysteine biosynthesis: structural and functional analysis of O-acetylserine sulfhydrylase from Arabidopsis thaliana. J Biol Chem 280, 38803-13
35. Arkus KAJ, Cahoon EB, Jez JM (2005) Mechanistic analysis of wheat chlorophyllase. Arch Biochem Biophys 438, 146-55
34. Jez JM, Cahoon RE (2004) Kinetic mechanism of glutathione synthetase from Arabidopsis thaliana. J Biol Chem 279, 42726-31
33. Jez JM, Cahoon RE, Chen S (2004) Arabidopsis thaliana glutamate-cysteine ligase: functional properties, kinetic mechanism, and regulation of activity. J Biol Chem 279, 33463-70
Kosan Biosciences, Inc. (2001-2002)
32. Jez JM, Chen JC, Rastelli J, Stroud RM, Santi DV (2003) Crystal structure and molecular modeling of 17-DMAG in complex with the N-terminal domain of human hsp90. Chem Biol 10, 361-8
Post-doc - Salk Institute (1998-2001)
31. Jez JM, Bowman ME, Noel JP (2002) Expanding the biosynthetic repertoire of type III polyketide synthases by altering starter molecule specificity. Proc Natl Acad Sci USA 99, 5319-24
30. Jez JM, Bowman ME, Noel JP (2002) The role of hydrogen bonds in the reaction mechanism of chalcone isomerase. Biochemistry 41, 5168-76
29. Jez JM, Noel JP (2002) Reaction mechanism of chalcone isomerase: pH-dependence, diffusion control, and product binding differences. J Biol Chem 277, 1361-9
28. Noel JP, Jez JM, Austin MB, Bowman ME, Ferrer JL (2002) Structurally guided alteration of biosynthesis in plant type III polyketide synthases in Recent Advances in Phytochemistry Vol. 36 – Phytochemistry in the Genomics and Post-Genomics Era (JT Romeo, Ed.) pp. 197-222, Plenum Press, New York
27. Jez JM, Ferrer JL, Bowman ME, Austin MB, Schröder J, Dixon RA, Noel JP (2001) Structure and mechanism of chalcone synthase-like polyketide synthases. J Ind Micro Biotech 27, 393-8
26. Jez JM, Bowman ME, Noel JP (2001) Structure-guided programming of polyketide chain-length determination in chalcone synthase. Biochemistry 49, 14829-38
25. Mallis RJ, Bruzin K, Jez JM, Wilson EK, Dieckmann GR, Robic S, Harrahy J (2001) Proteins: the complete works. Trends Biochem Sci 26, 642-3
24. Penning TM, Jez JM (2001) Enzyme redesign. Chem Rev 101, 3027-46
23. Jez JM, Noel JP (2000) Mechanism of chalcone synthase: pKa of the catalytic cysteine and the role of the conserved histidine in a plant-specific polyketide synthase. J Biol Chem 275, 39640-6
22. Jez JM, Austin MB, Ferrer J-L, Bowman ME, Schröder J, Noel JP (2000) Structural control of polyketide formation in plant-specific polyketide synthases. Chem Biol 7, 919-30
21. Jez JM, Bowman ME, Dixon RA, Noel JP (2000) Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase. Nature Struct Biol 7, 786-91
20. Jez JM, Noel JP (2000) A kaleidoscope of carotenoids. Nature Biotech 18, 825-6
19. Jez JM, Ferrer J-L, Bowman ME, Dixon RA, Noel JP (2000) Dissection of malonyl-CoA decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry 39, 890-902
18. Ferrer J-L, Jez JM, Bowman ME, Dixon RA, Noel JP (1999) Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis. Nature Struct Biol 6, 775-84