November 23, 2010

Building Addressable Libraries: The Use of “Safety-Catch” Linkers on Microelectrode Arrays

Bo Bi, Karl Maurer, and Kevin D. Moeller J. Am. Chem. Soc., 2010, 132 (49), 17405-17407

A “safety-catch” linker strategy has been used to site-selectively cleave and characterize molecules from a microelectrode array. The linkers are attached to the array by means of an ester and contain either a protected amine or protected alcohol nucleophile that can be released using acid generated at the microelectrodes.