October 27, 2005

Electrochemically Assisted Heck Reactions

Jun Tian and Kevin D. Moeller
Org. Lett., 2005, 7 (24), pp 5381–5383

During efforts to develop chip-based Heck reaction chemistry, it was discovered that normal solution-phase Heck reactions can be dramatically accelerated using electrochemistry. The acceleration makes room temperature Heck reactions proceed at synthetically useful rates in the absence of added ligand. Presumably, the current passed through the reaction maintains a high level of active catalyst.