While many steps in an oxidative cyclization reaction can be important, it is the cyclization step itself that plays the central role. If this step does not proceed well, then optimization of the rest of the sequence is futile.
In this Minireview, an electroorganic synthesis approach to the construction of addressable, complex molecular surfaces is described along with the parameters that guided the development of that synthetic approach.
While the majority of reported paired electrochemical reactions involve carefully matched cathodic and anodic reactions, the precise matching of half reactions in an electrolysis cell is not generally necessary.
While organic electrochemistry can look quite different to a chemist not familiar with the technique, the reactions are at their core organic reactions.
Oxidation reactions are powerful tools for synthesis because they allow us to reverse the polarity of electron-rich functional groups, generate highly reactive intermediates, and increase the functionality of molecules.
The electrochem. synthesis of pyrazolidine-3,5-diones and benzoxazoles by N-N bond formation and C,O linkage, resp., represents an easy access to medicinally relevant structures. Electrochem. as a key technol.
A novel electrochemical method for the synthesis of benzoxazoles from readily available anilides is reported. Various functionalities are tolerated and good yields can be achieved.
In electrochem. processes, an oxidn. half-reaction is always paired with a redn. half-reaction. Although systems for reactions such as the redn. of CO2 can be coupled to H2O oxidn. to produce O2 at the anode, large-scale O2 prodn.
