Publications

 

Vancomycin and oritavancin have different modes of action in Enterococcus faecium. Patti GJ, Kim SJ, Yu TY, Dietrich E, Tanaka KS, Parr TR Jr, Far AR, Schaefer J. J Mol Biol. 2009 Oct 9;392(5):1178-91. Epub 2009 Jul 1. PMID: 19576226

Oritavancin binds to isolated protoplast membranes but not intact protoplasts of Staphylococcus aureus. Kim SJ, Singh M, Schaefer J. J Mol Biol. 2009 Aug 14;391(2):414-25. Epub 2009 Jun 16. PMID: 19538971

Staphylococcus aureus peptidoglycan tertiary structure from carbon-13 spin diffusion. Sharif S, Singh M, Kim SJ, Schaefer J. J Am Chem Soc. 2009 May 27;131(20):7023-30. PMID: 19419167

Characterization of peptidoglycan in fem-deletion mutants of methicillin-resistant Staphylococcus aureus by solid-state NMR. Sharif S, Kim SJ, Labischinski H, Schaefer J. Biochemistry. 2009 Apr 14;48(14):3100-8. PMID: 19309106

15N{31P} REDOR NMR Studies of the Binding of Phosphonate Reaction Intermediate Analogues to Saccharomyces cerevisiae Lumazine Synthase. Yu TY, O'Connor RD, Sivertsen AC, Chiauzzi C, Poliks B, Fischer M, Bacher A, Haase I, Cushman M, Schaefer J. Biochemistry. 2008 Dec 3. PMID: 19053228

Hydrophobic side-chain length determines activity and conformational heterogeneity of a vancomycin derivative bound to the cell wall of Staphylococcus aureus. Kim SJ, Schaefer J. Biochemistry. 2008 Sep 23;47(38):10155-61. Epub 2008 Aug 30. PMID: 18759499

REDOR NMR characterization of DNA packaging in bacteriophage T4. Yu TY, Schaefer J. J Mol Biol. 2008 Oct 17;382(4):1031-42. Epub 2008 Aug 5. PMID: 18703073

Characterization of structural variations in the peptidoglycan of vancomycin-susceptible Enterococcus faecium: understanding glycopeptide-antibiotic binding sites using mass spectrometry. Patti GJ, Chen J, Schaefer J, Gross ML. J Am Soc Mass Spectrom. 2008 Oct;19(10):1467-75. Epub 2008 Jul 1. PMID: 18692403

Characterization of the peptidoglycan of vancomycin-susceptible Enterococcus faecium. Patti GJ, Kim SJ, Schaefer J. Biochemistry. 2008 Aug 12;47(32):8378-85. Epub 2008 Jul 19. PMID: 18642854

Vancomycin derivative with damaged D-Ala-D-Ala binding cleft binds to cross-linked peptidoglycan in the cell wall of Staphylococcus aureus. Kim SJ, Matsuoka S, Patti GJ, Schaefer J. Biochemistry. 2008 Mar 25;47(12):3822-31. Epub 2008 Feb 27. PMID: 18302341

Oritavancin exhibits dual mode of action to inhibit cell-wall biosynthesis in Staphylococcus aureus. Kim SJ, Cegelski L, Stueber D, Singh M, Dietrich E, Tanaka KS, Parr TR Jr, Far AR, Schaefer J. J Mol Biol. 2008 Mar 14;377(1):281-93. Epub 2008 Jan 17. PMID: 18258256

Dipolar double-quantum filtered rotational-echo double resonance. Matsuoka S, Schaefer J. Magn Reson Chem. 2007 Dec;45 Suppl 1:S61-4. PMID: 18157803

Multiple active site histidine protonation states in Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase detected by REDOR NMR. Schaefer J, Jiang H, Ransome AE, Kappock TJ. Biochemistry. 2007 Aug 21;46(33):9507-12. Epub 2007 Jul 27. PMID: 17655332

Double-quantum filtered rotational-echo double resonance. Matsuoka S, Schaefer J. J Magn Reson. 2006 Dec;183(2):252-8. Epub 2006 Sep 27. PMID: 17008112

Structures of Staphylococcus aureus cell-wall complexes with vancomycin, eremomycin, and chloroeremomycin derivatives by 13C{19F} and 15N{19F} rotational-echo double resonance. Kim SJ, Cegelski L, Preobrazhenskaya M, Schaefer J. Biochemistry. 2006 Apr 25;45(16):5235-50. PMID: 16618112

Conformational and quantitative characterization of oritavancin-peptidoglycan complexes in whole cells of Staphylococcus aureus by in vivo 13C and 15N labeling. Cegelski L, Steuber D, Mehta AK, Kulp DW, Axelsen PH, Schaefer J. J Mol Biol. 2006 Apr 7;357(4):1253-62. Epub 2006 Jan 30. PMID: 16483598

NMR determination of photorespiration in intact leaves using in vivo 13CO2 labeling. Cegelski L, Schaefer J. J Magn Reson. 2006 Jan;178(1):1-10. Epub 2005 Nov 10. PMID: 16289757

Glycine metabolism in intact leaves by in vivo 13C and 15N labeling. Cegelski L, Schaefer J. J Biol Chem. 2005 Nov 25;280(47):39238-45. Epub 2005 Sep 13. PMID: 16159873

Structure of a quinobenzoxazine--G-quadruplex complex by REDOR NMR. Mehta AK, Shayo Y, Vankayalapati H, Hurley LH, Schaefer J. Biochemistry. 2004 Sep 28;43(38):11953-8. PMID: 15379535

Structure of (KIAGKIA)3 aggregates in phospholipid bilayers by solid-state NMR. Toke O, O'Connor RD, Weldeghiorghis TK, Maloy WL, Glaser RW, Ulrich AS, Schaefer J. Biophys J. 2004 Jul;87(1):675-87. Erratum in: Biophys J. 2004 Aug;87(2):1397. PMID: 15240501

Secondary structure and lipid contact of a peptide antibiotic in phospholipid bilayers by REDOR. Toke O, Maloy WL, Kim SJ, Blazyk J, Schaefer J. Biophys J. 2004 Jul;87(1):662-74. PMID: 15240500

Characterization of the complex of a trifluoromethyl-substituted shikimate-based bisubstrate inhibitor and 5-enolpyruvylshikimate-3-phosphate synthase by REDOR NMR. McDowell LM, Studelska DR, Poliks B, O'Connor RD, Schaefer J. Biochemistry. 2004 Jun 1;43(21):6606-11. PMID: 15157093

Rotational-echo double-resonance NMR-restrained model of the ternary complex of 5-enolpyruvylshikimate-3-phosphate synthase. McDowell LM, Poliks B, Studelska DR, O'Connor RD, Beusen DD, Schaefer J. J Biomol NMR. 2004 Jan;28(1):11-29. PMID: 14739636

Compensating for pulse imperfections in REDOR. Weldeghiorghis TK, Schaefer J. J Magn Reson. 2003 Dec;165(2):230-6. PMID: 14643704

Rotational-echo double resonance of uniformly labeled 13C clusters. Mehta AK, Schaefer J. J Magn Reson. 2003 Jul;163(1):188-91. PMID: 12852923

REDOR with a relative full-echo reference. Mehta AK, Cegelski L, O'Connor RD, Schaefer J. J Magn Reson. 2003 Jul;163(1):182-7. PMID: 12852922

Conformation of a bound inhibitor of blood coagulant factor Xa. Studelska DR, McDowell LM, Adler M, O'Connor RD, Mehta AK, Guilford WJ, Dallas JL, Arnaiz D, Light DR, Schaefer J. Biochemistry. 2003 Jul 8;42(26):7942-9. PMID: 12834346

Human factor Xa bound amidine inhibitor conformation by double rotational-echo double resonance nuclear magnetic resonance and molecular dynamics simulations. McDowell LM, McCarrick MA, Studelska DR, O'Connor RD, Light DR, Guilford WJ, Arnaiz D, Adler M, Dallas JL, Poliks B, Schaefer J. J Med Chem. 2003 Jan 30;46(3):359-63. PMID: 12540235

Rotational-echo double resonance characterization of the effects of vancomycin on cell wall synthesis in Staphylococcus aureus. Cegelski L, Kim SJ, Hing AW, Studelska DR, O'Connor RD, Mehta AK, Schaefer J. Biochemistry. 2002 Oct 29;41(43):13053-8. PMID: 12390033

Rotational-echo double resonance characterization of vancomycin binding sites in Staphylococcus aureus. Kim SJ, Cegelski L, Studelska DR, O'Connor RD, Mehta AK, Schaefer J. Biochemistry. 2002 Jun 4;41(22):6967-77. PMID: 12033929

Investigation of the binding of epimer A of the covalent hydrate of 6,7-bis(trifluoromethyl)-8-D-ribityllumazine to a recombinant F22W Bacillus subtilis lumazine synthase mutant by (15)N[(19)F] REDOR NMR. Mehta AK, Studelska DR, Fischer M, Giessauf A, Kemter K, Bacher A, Cushman M, Schaefer J. J Org Chem. 2002 Apr 5;67(7):2087-92. PMID: 11925213

Relative CSA-dipolar orientation from REDOR sidebands. O'Connor RD, Schaefer J. J Magn Reson. 2002 Jan;154(1):46-52. PMID: 11820825