Uday worked on elucidating the mechanism of glutamine synthetase inhibition by tabtoxinine-beta-lactam and related inhibitors.
Neha Prasad was investigating the molecular mechanisms of obafluorin as an undergraduate researcher in our lab. She completed her B.S. in Chemistry, with a concentration in Biochemistry, in December 2016.
Angela is idenfifying and evaluating cycloguanil derivatives as inhibitors of dihydrofolate reductase. Outside of the lab, Angie enjoys spending time with friends, watching movies and exploring St. Louis.
Alex is investigating the kinetic profiles of several enzymes responsible for the degradation of tetracycline antibiotics in soil bacteria. Outside of the lab, Alex enjoys reading, writing, cooking, and singing.
Liz is synthesizing siderophore virulence factors produced by Acinetobacter baumannii for use in characterizing the multiple iron-transport pathways present in this Gram-negative pathogen.
Annika is isolating and purifying the salmycins, a family of siderophore-antibiotic conjugates produced by Streptomyces, to develop them as potent antibiotics against the superbug MRSA.
Tyler is developing new synthetic methods for making 3-hydroxy-beta-lactams like the one found in tabtoxin from Pseudomonas syringae.
Mars is investigating the timing and action of enzymes in the biosynthetic pathway of tabtoxin in the plant pathogen Pseudomonas syringae. Outside of the lab, Mars enjoys playing board games, doing crafts, and drinking craft beer.
Justin is studying siderophores produced by pathogenic Acinetobacter baumannii including acinetobactin which undergoes a curious nonenzymatic isomerization after cleavage from the NRPS assembly line.
Garrett is studying the timing and mechanism of beta-lactam formation in the biosynthesis of the phytotoxin tabtoxin produced by Pseudomonas syringae. Outside of the lab, Garrett enjoys running cross country and exploring St. Louis.
