Alan's work involves the application of molecular genetic techniques and statistical population genetics to a variety of evolutionary problems, both basic and applied. He applies evolutionary approaches to clinical genetics, including the study of the genetics of complex diseases, such as coronary artery disease and end-stage kidney disease. This work also involves the development of new bioinformatic tools at the single-gene to genomic levels. Alan also applies evolutionary genetics to conservation biology, with his main current focus being the impact of managed forest fires in the Ozarks at the landscape level upon the genetic population structure of species inhabiting that landscape, such as the Eastern collared lizard (Crotaphytus collaris collaris) and lichen hoppers (Trimerotropis saxatilis). In addiition, Alan is working on endangered species in Israel and is investigating the impact of human activities upon disperal in the endangered Wild Ass (Equus hemionis) in the Negev Desert in Southern Israel and in the endangered fire salamander (Salamandra salamandra infraimmuculata) in Northern Israel . He is also investigating how the fire salamander adapts at the individual level to diverse environments via changing gene expression profiles. Finally, Alan is interested in basic questions about evolution, such as the meaning of "species" and the mechanisms by which new species evolve, and human evolution over the last two million years.