We employ frequency agile gyrotrons and extreme cryogenic sample cooling to increase the sensitivity of solid state NMR experiments up to a factor of 20,000.

The drastic gain in sensitivity will permit biomolecular structure determination in complex heterogeneous systems in vitro with less than a milligram of sample and in hours of experimental time, or directly in vivo in a cellular context without protein purification.



Barnes DNP Laboratory

Louderman Hall, Room 346
Washington University in St. Louis
Department of Chemistry
Campus Box 1134
One Brookings Drive
St. Louis, MO 63130-4899

Email: barnesab@wustl.edu