December 12, 2017

Known Insertion/Deletion Mutations in Exon 9 of Heat Shock Transcription Factor 4 are not Responsible for Juvenile Hereditary Cataract in Siberian Husky Dogs

In this article, researchers explore how mutations in Exon 9, which is known for causing hereditary cataracts in the Staffordshire Bull Terrier, Boston Terrier, and Australian Shepard, are correlated to juvenile hereditary cataracts in the Siberian Husky. For this process, researchers used twelve related Siberian Huskies. Initially, four of the twelve were diagnosed with primary hereditary cataracts, while the other eight were normal at the initial ophthalmological examination.  The dogs that were diagnosed all had onset of cataracts before the age of eighteen months. However, at this time the researchers did not know how Huskies inherited hereditary cataracts.

In order to find the cause of hereditary cataracts, the researchers used genetic testing to determine the cause. Through this process, they found that all the animals that were tested had the same length of polymerase chain reactions as that of normal, healthy dogs. In addition, scientists found that the mutations known for causing hereditary cataracts in the Staffordshire Bull Terrier, Boston Terrier, and Australian Shepard are not the same as that which causes hereditary cataracts in Siberian Huskies.



 

Reviewed by: Danielle Folkerts

 

Gentilin, Fabio, et al. “Known Insertion/Deletion Mutations in Exon 9 of Heat Shock Transcription Factor 4 are not Responsible for Juvenile Hereditary Cataract in Siberian Husky Dogs.” Animal Genetics, vol. 39, 2008, pp. 575–576.

 

Link: /files/pages/imce/dogbreeds/anim-genetics-hstf4.pdf