Conformational changes in the di-domain structure of Arabidopsis phosphoethanolamine methyltransferase leads to active site formation (Lee & Jez, 2017 J Biol Chem 292, 21690-702)

Plants are amazing chemists capable of generating an array of compounds with a range of biological activities. Understanding the biosynthesis of these compounds at a structural and mechanistic level is the foundation for manipulating their assembly either in vitro or in vivo. Our research employs biochemistry, protein engineering, and x-ray crystallography to investigate the molecular basis of biological processes in plants, microbes, and nematodes.