December 11, 2013

Cyclization Reactions of Anode-Generated Amidyl Radicals

Hai-Chao Xu, John M. Campbell, and Kevin D. Moeller

J. Org. Chem., 2014, 79 (1), pp 379–391

Amidyl radicals have been generated from amides under mild conditions electro-oxidatively. Their reactivity toward electron-rich double bonds to form five- and six-membered rings has been demonstrated experimentally and explored with density functional theory (DFT) calculations (UB3LYP/6-31G(d,p))