October 29, 2009

A New Porous Reaction Layer for Developing Addressable Molecular Libraries

Libo Hu, Jennifer L. Bartels, Jeremy W. Bartels, Karl Maurer and Kevin D. Moeller

J. Am. Chem. Soc., 2009, 131(46), 16638–16639

A new diblock copolymer-derived porous reaction layer for microelectrode arrays has been tested for its stability and its compatibility with both site-selective synthesis and electrochemical signaling experiments. The diblock copolymer consisted of a cinnamoyl-substituted polymethacrylate block for attachment to the surface of the array and a bromo-substituted polystyrene block for selective functionalization of the surface proximal to microelectrodes in the array. Site-selective Suzuki, Heck, and Cu(I)-coupling reactions were all performed on the new reaction layer along with electrochemical impedance studies.