Katherine Hughes Schreiber

Katherine Hughes Schreiber

Center for Engineering Mechanobiology Fellow

BS. Department of Biology, Univeristy of Dayton

PhD, Biochemistry, Saint Louis Univeristy

Postdoctoral Fellow, Department of Biochemistry, University of Washington / The Buck Institute for Research on Aging

Bay Area Aging Meeting "Best Postdoctoral Poster" Award, 2013
National Service Research Award (NRSA) Postdoctoral Fellowship, 2012-2014
National Service Research Award (NRSA) Predoctoral Training Fellow, 2005-2007
Saint Louis University "Excellence in Research" Award, 2007
University of Dayton President's Merit Scholarship, 2000-2004

Schreiber, K. H., Ortiz, D., Academia, E. C., Anies, A. C., Liao, C., and Kennedy, B. K (2016). Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins. Aging Cell. 14(2): 265-73.

Schreiber, K. H., Ortiz, D., Academia, E. C., Anies, A. C., Liao, C., and Kennedy, B. K (2015). Rapamycin-mediated

mTORC2 inhibition is determined by the relative expression of FK506-binding proteins. Aging Cell. 14(2): 265-

73. PMID:25652038


Schreiber, K. H., O’Leary, M. N., Kennedy, B. K. (2015). The mTOR pathway and aging. In Handbook of the Biology

of Aging (8th ed). Waltham, MA. Academic Press.


Oleson B.J., Broniowska K.A., Schreiber K.H., Tarakanova V.L., Corbett J.A. (2014). Nitric Oxide Induces Ataxia

Telangiectasia Mutated (ATM) Protein-dependent γH2AX Protein Formation in Pancreatic β Cells. J Biol Chem.

289(16): 11454-64. PMID:24610783


Garelick , M. G., Mackay, V. L., Yanagida, A., Academia, E. C., Schreiber, K. H., Ladiges, W. C. and Kennedy, B. K.

(2013). Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo. Cell Cycle

12(15): 2493-2504. PMID:23839034


O'Leary, M. N., Schreiber, K. H., Zhang, Y., Duc, A. C., Rao, S., Hale, J. S., Academia, E. C., Shah, S. R., Morton, J. F.,

Holstein, C. A., Martin, D. B., Kaeberlein, M., Ladiges, W. C., Fink, P. J., Mackay, V. L., Wiest, D. L. and Kennedy,

B. K. (2013). The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its

own paralog, Rpl22l1. PLoS Genet 9(8): e1003708. PMID:23990801


Schreiber, K. H. and Kennedy, B. K. (2013). When lamins go bad: nuclear structure and disease. Cell 152(6): 1365-

1375. PMID:23498943


Ramos, F. J., Chen, S. C., Garelick, M. G., Dai, D. F., Liao, C. Y., Schreiber, K. H., MacKay, V. L., An, E. H., Strong, R.,

Ladiges, W. C., Rabinovitch, P. S., Kaeberlein, M. and Kennedy, B. K. (2012). Rapamycin reverses elevated

mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends

survival. Sci Transl Med 4(144): 144ra103. PMID:22837538


Hughes, K. J. and Kennedy, B. K. (2012). Cell biology. Rapamycin paradox resolved. Science 335(6076): 1578-1579.



Andreone, T., Meares, G. P., Hughes, K. J., Hansen, P. A. and Corbett, J. A. (2012). Cytokine-mediated beta-cell

damage in PARP-1-deficient islets. Am J Physiol Endocrinol Metab 303(2): E172-179. PMID:22535743


Hughes, K. J., Meares, G. P., Hansen, P. A. and Corbett, J. A. (2011). FoxO1 and SIRT1 regulate beta-cell responses

to nitric oxide. J Biol Chem 286(10): 8338-8348. PMID:21196578


Meares, G. P., Hughes, K. J., Naatz, A., Papa, F. R., Urano, F., Hansen, P. A., Benveniste, E. N. and Corbett, J. A.

(2011). IRE1-dependent activation of AMPK in response to nitric oxide. Mol Cell Biol 31(21): 4286-4297.



Lim, D. J., Antipenko, S. V., Anderson, J. M., Jaimes, K. F., Viera, L., Stephen, B. R., Bryant, S. M., Yancey, B. D.,

Hughes, K. J., Cui, W., Thompson, J. A., Corbett, J. A. and Jun, H. W. (2011). Enhanced rat islet function and

survival in vitro using a biomimetic self-assembled nanomatrix gel. Tissue Eng Part A 17(3-4): 399-406.



Meares, G. P., Hughes, K. J., Jaimes, K. F., Salvatori, A. S., Rhodes, C. J. and Corbett, J. A. (2010). AMP-activated

protein kinase attenuates nitric oxide-induced beta-cell death. J Biol Chem 285(5): 3191-3200. PMID:19933272


Hughes, K. J., Meares, G. P., Chambers, K. T. and Corbett, J. A. (2009). Repair of nitric oxide-damaged DNA in betacells

requires JNK-dependent GADD45alpha expression. J Biol Chem 284(40): 27402-27408. PMID:19648647


Hughes, K. J., Chambers, K. T., Meares, G. P. and Corbett, J. A. (2009). Nitric oxides mediates a shift from early

necrosis to late apoptosis in cytokine-treated beta-cells that is associated with irreversible DNA damage. Am J

Physiol Endocrinol Metab 297(5): E1187-1196. PMID:19738038


Klein, C., Creach, K., Irintcheva, V., Hughes, K. J., Blackwell, P. L., Corbett, J. A. and Baldassare, J. J. (2006). Zinc

induces ERK-dependent cell death through a specific Ras isoform. Apoptosis 11(11): 1933-1944.