Communication

Hard at work in the Journal Sentinel newsroom
July 27, 2015

Why my sources are (usually) happy to talk to me

Reporting on science shows me the links between journalism and research
Mid-way through my experience as a science journalist for the summer, I realized that unlike some of my colleagues in the newsroom around me, my sources were usually happy to talk with me about their work—the process, the scope, and the limitations.
March 4, 2011

Anodic Coupling Reactions: Exploring the Generality of Curtin−Hammett Controlled Reactions

Alison Redden and Kevin D. Moeller

Org. Lett., 2011, 13 (7), 1678–1681

Intramolecular anodic olefin coupling reactions can be compatible with the presence of dithioketal protecting groups even though the dithioketal oxidizes at a lower potential than either of the groups participating in the cyclization. In such cases, product formation is controlled by the Curtin−Hammett Principle. In this study, the generality of such reactions is examined along with the use of alternative reaction conditions to suppress unwanted side reactions.

 

September 13, 2010

Intramolecular Anodic Olefin Coupling Reactions: Use of the Reaction Rate to Control Substrate/Product Selectivity

Hai-Chao Xu and Kevin D. Moeller

Angew. Chem. Int. Ed. 2010, 49, 8004–8007

Look out—it’s a trap! The anodic coupling of olefins with amine trapping groups to form proline and pipecolic acid derivatives with a quaternary α carbon atom (see scheme) was successful despite the significantly lower oxidation potential of the product relative to that of either functional group in the substrate: owing to the very fast cyclization, the oxidation potential of the substrate is lower than that of the product.

 

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