Publications

·       Keedy, H.E. Thomas, E.N., and Zaher, H.S. (2018) “Decoding on the ribosome depends on the structure of the mRNA phosphodiester backbone” Proc Natl Acad Sci USA, 115(29):E6731-E6740

·       Simms, C. L., Yan, L.L. and Zaher H.S. (2017) “Ribosome collision is critical for quality control during no-go decay” Mol Cell68(2):361-373

·       Arefanian S., Schäll D., Chang S., Ghasemi R., Higashikubo R., Zheleznyak A., Guo Y., Yu J., Asgharian H., Li W., Gelman A.E., Kreisel D., French A.R., Zaher H., Plougastel-Douglas B., Maggi L., Yokoyama W., Beer-Hammer S., Krupnick A.S. (2016) “Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance”. Oncoimmunology, 5(12):e1238543.

·       Pierson, W.E., Hoffer, E., Keedy, H.E., Simms, C.L., Dunham, C.M. and Zaher H.S. (2016) “Uniformity of peptide release is maintained by methylation of release factors” Cell reports17(1):11-8

·       Simms, C.L., Thomas, E.N. and Zaher, H.S. (2016) “Ribosome-based Quality Control Mechanisms” Wiley Interdiscip Rev RNA. doi: 10.1002/wrna.1366 (Invited review).

·       Simms, C.L. and Zaher, H.S. (2016) “Quality control of chemically damaged RNA” Cellular and Molecular Life Sciences73(19):3639-53 (Invited review)

·       Carle, C.M., Zaher, H.S. and Chalker, D.L. (2016) “A parallel G quadruplex-binding protein regulates the boundaries of DNA elimination events of Tetrahymena thermophile” PLOS Genetics12(3):e1005842.

·       Hudson, B.H. and Zaher, H.S. (2015) “O6-Methylguanosine leads to position-dependent effects on ribosome speed and fidelity”. RNA, 21(9):1648-1659.

·       Djuranovic, S.D. and Zaher, H.S. (2015) “Targeted mRNA degradation” in Encyclopedia of Cell Biology, Hart, Goud, Raposo, Ezekowitz and Lauffenburger, eds (Elsevier, Oxford, UK). (Book chapter)

·       Simms, C.S., Hudson, B.H., Mosior, J.W., Rangwala A. S. and Zaher, H.S.  (2014) “An active role for the ribosome in determining the fate of oxidized mRNA”. Cell reports, 9(4):1256-1264. 

·       Hudson, B.H. and Zaher, H.S. (2014) “Ribosomes left in the dust: diverse strategies for peptide-mediated translation stalling". Mol. Cell. 56(3):345-346.

·       Petropoulos, A. D., McDonald, M. E., Green, R. and Zaher, H. S. (2014) “Distinct roles for release factor 1 and release factor 2 in translational quality control”. J. Biol. Chem., 289(25):17589-96.

·       Zaher, H. S. and Green, R. (2014) “In vitro synthesis of proteins in bacterial extracts”. Methods Enzymol. 539:3-15.

·       Zaher, H. S. and Green, R. (2011) “A primary role for release factor 3 in quality control during translation elongation in Escherichia coli”. Cell147(2):396-408.

·       Miller, M. R., Liu, Z., Cazier, D. J., Gebhard, G. M., Herron, S. R., Zaher, H. S., Green, R. and Buskirk, A. R. (2011) “The role of SmpB and the ribosomal decoding center in licensing tmRNA entry into stalled ribosomes”. RNA17(9):1727-36.

·       Zaher, H. S., Shaw, J. J., Strobel, S. A. and Green, R. (2011) “The 2'-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC”. EMBO J30(12):2445-53.

·       Ortiz-Meoz, R. F., He, S. L., Zaher, H. S. and Green, R. (2011) “Sense and nonsense recognition by the ribosome” in Ribosomes Structure, Function, and Dynamics, Rodnina, M. V.; Wintermeyer, W.; Green, R., eds. (Springer-Verlag, New York). (Book Chapter)

·       Zaher, H. S. and Green, R. (2010) “Kinetic basis for global loss of fidelity arising from mismatches in the P-site codon:anticodon helix”. RNA16(10):1980-9.

·       Zaher, H.S. and Green, R. (2010) “Hyperaccurate and error-prone ribosomes exploit distinct mechanisms during tRNA selection”. Molecular Cell39(1):110-20.

·       Zaher, H. S. and Green, R. (2009) “Quality control on the ribosome following peptide bond formation”. Nature, 457(7226): 161-166.

·       Zaher, H. S. and Green, R. (2009) “Fidelity at the molecular level: lessons from protein synthesis”. Cell, 136(4): 746-762. (Review)

·       Zaher, H. S. and Unrau, P. J. (2007) “Selection of an improved RNA polymerase ribozyme with superior extension and fidelity”. RNA, 13(7):1017-26.

·       Zaher, H. S. and Unrau, P. J. (2006) “A general RNA-capping ribozyme retains stereochemistry during cap exchange”. JACS, 128(42):13894-900.

·       Zaher, H. S., Watkins, R. A. and Unrau, P. J. (2006) “Two distinct capping ribozymes have highly convergent catalytic properties”. RNA, 12(11):1949-58.

·       Zaher, H. S. and Unrau, P. J. (2005) “Nucleic acid library construction using synthetic DNA constructs”. Methods Mol Biol. 288: 359-378. (Book Chapter)

·       Zaher, H. S. and Unrau, P. J.  (2004) “T7 RNA polymerase mediates fast promoter-independent extension of unstable nucleic complexes.” Biochemistry 43(24): 7873-7880.

 

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